Twinject®

The Simplicity of an Auto-injector

The Twinject auto-injector delivers epinephrine rapidly and easily. Epinephrine is the most effective treatment available for anaphylaxis.¹ It is administered by injection through the skin into the thigh, and begins working immediately. Epinephrine relaxes constricted airways in the lungs and reverses dropping blood pressure.

The convenience of a second dose

Up to 1 out of every 5 patients may require more than 1 dose of epinephrine.² A second dose may be needed within 10 minutes of the first. For this reason, it is very important to have a second, prepared dose of epinephrine nearby during an anaphylactic reaction.

Twinject is the only available auto-injector that provides 2 doses of epinephrine in 1 device. Twinject comes with a light-weight slim carrying case for protection of the auto-injector.

Each Twinject comes with:

Simple, easy to follow first-dose directions printed on the side of the auto-injector
A slim, crush-resistant case protects drug from sunlight and tucks easily into purses, pockets, and backpacks
A permanently attached wrap label with clear step-by-step directions for the second dose
Thin, 25-gauge needle

Available in 2 dosing strengths

Twinject 0.15 mg is for those weighing between 33 and 66 pounds (approximately 15-30 kilograms)
Twinject 0.3 mg is for those who weigh 66 pounds (approximately 30 kilograms) or more

Twinject Two-Pack for protection at home and away

Twinject may also be prescribed as a Two-Pack, which includes 2 Twinject auto-injectors. Storing Twinject auto-injectors in multiple locations helps ensure that protection is always within reach—at school, at home, and on the go. The Twinject Two-Pack also includes a take-home practice device to help caregivers and family members learn how to give a Twinject injection. If you currently have a Twinject single prescription, ask your doctor if the Twinject Two-Pack is right for you.

Scroll down for Important
Safety Information.

INDICATION:

Twinject (epinephrine injection, USP 1:1000) is indicated in the emergency treatment of severe allergic reactions (Type I) including anaphylaxis to stinging insects (e.g. order Hymenoptera, which includes bees, wasps, hornets, yellow jackets and fire ants), and biting insects (e.g. triatoma, mosquitoes), allergen immunotherapy, foods, drugs, diagnostic testing substances (e.g. radiocontrast media), and other allergens, as well as anaphylaxis to unknown substancess (idiopathic anaphylaxis) or exercise-induced anaphylaxis.

IMPORTANT SAFETY INFORMATION ABOUT TWINJECT:

Twinject should only be injected into the anterolateral aspect of the thigh. Accidental injection into the hands or feet may result in loss of blood flow to the affected area and should be avoided. DO NOT INJECT INTO BUTTOCK. DO NOT INJECT INTRAVENOUSLY.

Epinephrine should be administered with caution to patients with cardiac arrhythmias, coronary artery or organic heart disease, or hypertension. In patients with coronary insufficiency or ischemic heart disease, epinephrine may precipitate or aggravate angina pectoris as well as produce ventricular arrhythmias. It should be recognized that the presence of these conditions is not a contraindication to epinephrine administration in an acute life-threatening situation.

Adverse reactions to epinephrine may include flushing; apprehension; syncope; tachycardia; thready pulse with a fall in blood pressure; convulsions; respiratory difficulties; vomiting, diarrhea or cramps; pruritus; or angioderma. Twinject is designed as an emergency supportive therapy only and is not a replacement or substitute for immediate medical care.

Since the doses of epinephrine delivered from Twinject are fixed, the physician should consider other forms of injectable epinephrine if doses lower than those available from Twinject are felt to be necessary (e.g., patients who weigh less than 15 kilograms approximately 33 pounds). IN ALL CASES, THE PHYSICIAN SHOULD INSTRUCT THE PATIENT AND/OR ANY OTHER PERSON WHO MIGHT BE IN A POSITION TO ADMINISTER THE EPINEPHRINE, IN THE PROPER USE OF TWINJECT.

Please see complete prescribing information for more details.

Your doctor can give you more information about Twinject or call 1-888-TWIN-JCT. Ask your doctor if Twinject may be right for you.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.FDA.gov/medwatch or call 1-800-FDA-1088

MedicAlert^® is a Federally Registered Trademark and Service Mark.
MedicAlert and Kid Smart are registered trademarks and service marks of their respective owners.

Twinject is a registered trademark of Sciele Pharma, Inc.
© 2008 Sciele Pharma, Inc. Atlanta, Georgia. All rights reserved. TWI.07.08.036.03

This web site and its contents are intended for use only by residents of the United States. Products discussed may have different labeling, regulatory requirements, and/or medical practices in other countries that may require reference to different or additional information.

References:

1. John A. Anderson, MD, David I. Bernstein, MD, Jonathan A. Bernstein, MD, Jordan N. Fink, MD, Paul A. Greenberger, MD, Dennis K. Ledford, MD, James Li, MD, PhD, Albert L. Sheffer, MD, Roland Solensky, MD, and Bruce L. Wolf, MD. The Diagnosis and Management of Anaphylaxis An Updated Practice Parameter, 2005, S491. 2. Anne K. Ellis, MD, FRCPC, and James H. Day, MD, FRCPC. Incidence and characteristics of biphasic anaphylaxis: a prospective evaluation of 103 patients. ANNALS OF ALLERGY, ASTHMA & INMUNOLOGY, 2007, 64-69.